Family doctor



FLUCLOXACILLIN - a patient's guide


This medicine is mainly used to treat skin and chest infections. This article profiles the drug, its uses and side effects.

Brand name:

  • Floxapen
  • Flucloxin
  • Staphlex

Use: Antibiotic - narrow spectrum penicillin

Flucloxacillin is a narrow spectrum antibiotic that has specific activity against pencillinase-producing bacteria. These bacteria are responsible for antibiotic-resistance amongst certain skin, chest, and soft tissue infections. Therefore, flucloxacillin is indicated mainly for these type of infections.

This medicine is well absorbed in the stomach therefore is best taken on an empty stomach unlike most other antibiotics.


  • Allergy to penicillins
  • Kidney and liver impairment
  • Breastfeeding and pregnancy (discuss with doctor)
  • Jaundice

Side effects:

Occasional: stomach upset and skin rash

Blood disorders, kidney, and liver damage have been reported in rare cases.


Excretion is delayed by probenecid.

Patient information:

  • Follow the instructions on the label of the medicine or as directed by your doctor
  • Always complete the course of antibiotics unless directed by your doctor, or a skin rash develops
  • Food: taken on an empty stomach (one hour before or two hours after meals)
  • Alcohol: Little problems in moderation
  • Contact your doctor or seek urgent medical treatment if side effects are severe or ongoing.

See also:

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